NEPHROLOGY: The natural history of renal tubular acidosis: Lightwood's syndrome revisitied

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FRONTIERS IN NEPHROLOGY Renal Tubular Acidosis: The Clinical Entity

The term renal tubular acidosis (RTA) is applied to a group of transport defects in the reabsorption of bicarbonate (HCO3 ), the excretion of hydrogen ion (H ), or both. This condition was first described in 1935 (1), confirmed as a renal tubular disorder in 1946 (2), and designated “renal tubular acidosis” in 1951 (3). The RTA syndromes are characterized by a relatively normal GFR and a metabo...

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FRONTIERS IN NEPHROLOGY Inherited Distal Renal Tubular Acidosis

Renal acid-base balance may become deranged in a number of ways, some of which are the consequence of inherited disorders. Two main groups of distal renal acidopathies result either from a direct inability to secrete acid in the distal nephron (giving rise to type 1 renal tubular acidosis [RTA]) or as an inherited or functional consequence of hypoaldosteronism, leading to type 4 (hyperkalemic) ...

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PROLONGED PARALYSIS AS AN UNUSUAL PRESENTATION OF RENAL TUBULAR ACIDOSIS

A case of renal tubular acidosis (RTA) who had gradual onset of paralysis of lower extremities and persisted for a long time is presented. His primary workups were mistaken for muscular dystrophy. Eventually, an abdominal ultrasonography revealed small stones in both of the kidneys and his workup for the stones were in favor of distal renal tubular acidosis and advanced rickets with hypokal...

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The spectrum of renal tubular acidosis in paediatric Sjögren syndrome.

OBJECTIVES Renal tubular acidosis (RTA) is a well-recognized extraglandular complication of adult Sjögren syndrome (SS) but has been reported only rarely in paediatric SS. We wished to describe the natural history of RTA in paediatric SS. METHODS We performed a chart and literature review. Inclusion criteria were primary or secondary SS with onset before 18 yr of age, complicated by RTA befor...

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Renal tubular acidosis.

Renal tubular acidosis is a relatively uncommon clinical syndrome characterized by the inability of the kidney to adequately excrete hydrogen ions, retain adequate bicarbonate, or both. This syndrome can be categorized into 3 separate disorders, each with unique clinical characteristics. Although an uncommon finding, prompt and inexpensive tests can lead to early intervention and subsequently r...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1971

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-197108000-00046